Redefining precision

A pathway to cancer-related immunoassays

Proclarix biomarkers were identified at the Swiss Federal Institute of Technology in Zurich (ETH Zurich) using a genetics-guided discovery approach focusing on the PI3K/PTEN cancer pathway. The latest proteomics technologies were used to analyze glycosylated proteins in prostate tissue and serum from wild-type mice and mice with prostate-specific deletion of the tumor suppressor PTEN. These findings were then translated into a blood-based test that measures cancer-related proteins in highly reproducible immunoassays.

Informed decisions with Proclarix

Proclarix (CE-IVD) is a breakthrough in identifying patients with elevated PSA who actually require more medical investigation. Proclarix is indicated in men with elevated total PSA (2.0 to 10.0 ng/ml) and a digital rectal examination finding consistent with elevated prostate volume (≥35 ml), but who are not suspected of having cancer. The Proclarix Risk Score identifies patients with a Gleason Score ≥7 in whom detecting high-grade prostate cancer with a prostate biopsy is probable.

A ready-to-use solution

Proclarix consists of two quantitative Enzyme-Linked Immunosorbent Assays (ELISA) that measure the concentration of thrombospondin 1 (THBS1) and cathepsin D (CTSD) respectively in human serum. A proprietary software integrates the values for THBS1 and CTSD, with age as well as total and free PSA to calculate the patient's Proclarix Risk Score.

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Proclarix Instruction for Use (IFU)

Report shows the risk of high-grade prostate cancer

Proclarix integrates several proprietary biomarkers into a multidimensional signature of each patient's cancer-related proteins. The doctor receives a full report on all biomarker results and obtains a cumulative score giving a precise assessment of the prostate cancer risk.

Find further information about Proclarix and how to be tested for prostate cancer at your local laboratory.

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